the effects of vitamin e and selenium on cisplatin-induced nephrotoxicity in cancer patients treated with cisplatin-based chemotherapy: a randomized, placebo-controlled study
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comment on: the effects of vitamin e and selenium on cisplatin-induced nephrotoxicity in cancer patients treated with cisplatin-based chemotherapy: a randomized, placebo-controlled study
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متن کاملComment on: The effects of Vitamin E and Selenium on cisplatin-induced nephrotoxicity in cancer patients treated with cisplatin-based chemotherapy: A randomized, placebo-controlled study
| October 2013 | 922 much attention has been made toward kidney protective efficiency of selenium. The results of the study conducted by Randjelovic et al., showed selenium supplementation attenuates oxidative-stress-associated renal injury by reducing oxygen free radicals and lipid peroxidation in gentamicin-treated rats,[4] while gentamicin-renal damage in Wistar rats is a model of acute kidn...
متن کاملThe effects of vitamin E and selenium on cisplatin-induced nephrotoxicity in cancer patients treated with cisplatin-based chemotherapy: A randomized, placebo-controlled study
| July 2013 | 625 study on rat model of CP nephrotoxicity and observed, losartan may prevent CIN in males, but it promotes the CP‐induced damage in females, which may be related to the renin‐angiotensin system receptors in the kidneys.[7] Additionally, we recently reported that, vitamin E, vitamin C, or losartan is not nephroprotectant against CIN in presence of estrogen in ovariectomized rat m...
متن کاملThe Effect of Vitamin E on Cisplatin Induced Nephrotoxicity: A Clinical Trial Study
Background Cisplatin is a common platinum based chemotherapy drug that is commonly used for the treatment of the solid tumors. It is believed that this drug has nephrotoxic effects due to its oxidative action. Therefore, it is believed antioxidant agents such as vitamin...
متن کاملEffect of Simvastatin on Cisplatin-induced Nephrotoxicity in Male Rats
Statins have antioxidant and anti-inflammatory effects that are not directly related to their cholesterol-lowering activity. This study aimed to investigate the effect of simvastatin on the extent of tissue damage in cisplatin-induced nephrotoxicity. Simvastatin was orally given to rats in different doses (1, 2 and 4 mg/kg), 1 h prior to cisplatin injection (5 mg/kg, i.p.). All animals we...
متن کاملRenal protective effect of selenium on cisplatin-induced nephrotoxicity
*Corresponding author: Ali Ghorbani M.D, Department of Nephrology, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. E-mail: [email protected] Implication for health policy/practice/research/medical education: Selenium supplementation reduces the products of oxidative stress in kidney failure patients and can be protective against cisplatin nephrotoxicity. ...
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عنوان ژورنال:
journal of research in medical sciencesجلد ۱۸، شماره ۷، صفحات ۶۲۵-۰
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